Human cyclic nucleotide phosphodiesterases possess a much broader substrate-specificity than previously appreciated

Cyclic nucleotide phosphodiesterases in neoplastic and nonneoplastic human mammary tissues.

Cyclic nucleotide phosphodiesterase activity was studied in 33 malignant neoplastic, 2 benign neoplastic, and 18 nonneoplastic human mammary tissues. Enzyme activity, using both cyclic adenosine 3':5'-monophosphate and cyclic guanosine 3':5'-monosphosphate as substrates, was measured in whole homogenates over a concentration range of 1 to 100 muM. Specific activity was calculated at substrate c...

Cyclic AMP compartments and signaling specificity: Role of cyclic nucleotide phosphodiesterases

Multiple cyclic nucleotide phosphodiesterases in human trabecular meshwork cells.

PURPOSE To characterize cyclic nucleotide phosphodiesterase isozyme activities in human trabecular meshwork cells and primary cultures of porcine trabecular meshwork cells. METHODS Radioimmunoassay of acetylated acid extracts was used to determine changes in cyclic adenosine monophosphate (cAMP) and cyclic quanosine monophosphate (cGMP) in human trabecular meshwork cells treated with phosphod...

Cyclic Nucleotide Phosphodiesterases and Thyroid Hormones*

Evidence is presented that modulation of the maximum velocity of a particulate low K,,, cyclic adenosine 3’:5’-monophosphate (cyclic AMP) phosphodiesterase by thyroid hormones is one mechanism for the regulation of the responsiveness of rat epididymal adipocytes to lipolytic agents such as epinephrine and glucagon. Fat cells of propylthiouracil-induced hypothyroid rats are unresponsive to lipol...

The biology of cyclic nucleotide phosphodiesterases.

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